ISSN 0430-6252. Physicochemical Mechanics of Materials. 2024.
Volume 60, Issue 1

Mechanical and magnetic properties of biocomposites based on hydroxyapatite modified with magnetite and chitosan

Keywords

biogenic hydroxyapatite, magnetite, chitosan, composite, magnetic and me¬cha¬nical properties.

Cite as

Synytsia А. О., Sych О. Ye., Yevich Ya. І., Vedel D. V., Babutina Т. Ye., Kondratenko І. H., and Perekos А. О. Mechanical and magnetic properties of biocomposites based on hydroxyapatite modified with magnetite and chitosan. Physicochemical Mechanics of Materials. 2024. 60(1), 049-056.

https://doi.org/10.15407/pcmm2024.01.049

Abstract

Mechanical and magnetic properties of composites based on biogenic hydroxyapatite modified with magnetite (1; 5; 25 and 50 wt%) and chitosan are studied. An increase in the content of magnetite in the composite from 1 to 50 wt% leads to a slight decrease in porosity (from 45 to 38%) and to a significant increase in compressive strength and Young’s modulus (in 7 times with the addition of magnetite obtained by chemical precipi­tation and in 3 times with the addition of magne­tite obtained by thermolysis), compared to pure hydroxyapatite. With an increase in the amount of magnetite, regardless of its type (synthesis method), the magne­tic properties of composites are also impoved. Taking into account the mechanical properties which are close to porous human bone and magnetic properties sufficient for hyperthermia treatment, magnetotherapy or targeted drug delivery, the obtained biogenic hydroxyapatite–magne­tite–chitosan composites are promising in biomedicine.

References

  1. А. S. Masyuk, V. E. Levytskyi, Kh. V. Kysil, D. S. Katruk, L. М. Bilyi, and T. V. Humenetskyi, “Influence of calcium phosphates on the morphology and properties of polylactide composites,” Sci., 56, No. 6, 870-876 (2021). https://doi.org/10.1007/s11003-021-00506-5
  2. T. Varadavenkatesan, R. Vinayagam, S. Pai, K. Brindhadevi, A. Pugazhendhi, and R. Selvaraj, “Synthesis, biological and environmental applications of hydroxyapatite and its composites with organic and inorganic coatings,” Prog. Org. Coat., 151, Is.4 (2021). Article number 106056. https://doi.org/10.1016/j.porgcoat.2020.106056
  3. O. V. Tkachuk, R. V. Proskurnyak, and M. Ya. Holovchuk, “Morphology of hydroxyapatite coatings formed on VT1-0 titanium as a result of combined treatment,” Mater. Sci., 58, No. 1, 75-79 (2022). https://doi.org/10.1007/s11003-022-00633-7
  4. D. O. Obada, S. A. Osseni, H. Sina et al., “Hydroxyapatite materials-synthesis routes, mechanical behavior, theoretical insights, and artificial intelligence models: a review,” J. Aus-tralian Ceram. Soc., 59, 565-596 (2023). https://doi.org/10.1007/s41779-023-00854-2
  5. J. M. Bouler, M. Trecant, J. Delecrin, J. Royer, N. Passuti, and G. Daculsi, “Macroporous biphasic calcium phosphate ceramics: Influence of five synthesis parameters on compressive strength,” J. Biomed. Mater. Res., 32, 603-609 (1996). https://doi.org/10.1002/(SICI)1097-4636(199612)32:4<603::AID-JBM13>3.0.CO;2-E
  6. W. L. Suchanek, and M. Yoshimura, “Processing and properties of hydroxyapatite-based bio-materials for use as hard tissue replacement implants,” J. Mater. Res., 13, 94-117 (1998). https://doi.org/10.1557/JMR.1998.0015
  7. M. Afifi, M. E. El-Naggar, S. Muhammad, N. A. Alghamdi, S. Wageh, S. R. Salem, D. Alhashmialameer, and M. A. Taleb, “Nanocomposites based on hydroxyapatite/lithium oxide and graphene oxide nanosheets for medical applications,” J. Mater. Sci., 57, 11300-11316 (2022). https://doi.org/10.1007/s10853-022-07342-1
  8. Y. Li, X. Liu, B. Gaihre, L. Li, A. Rezaei, A. L. Miller II, B. Waletzki, S. Park, A. Terzic, and L. Lu, “Zinc-doped hydroxyapatite and poly (propylene fumarate) nanocomposite scaffold for bone tissue engineering,” J. Mater. Sci., 57, 5998-6012 (2022). https://doi.org/10.1007/s10853-022-06966-7
  9. Y. Song, Q. Hu, Q. Liu, S. Liu, Y. Wang, and H. Zhang, “Design and fabrication of drug-loaded alginate/hydroxyapatite/collagen composite scaffolds for repairing infected bone defects,” J. Mater. Sci., 58, 911-926 (2023). https://doi.org/10.1007/s10853-022-08053-3
  10. A. Pistone, D. Iannazzo, C. Celesti, E. Piperopoulos, D. Ashok, A. Cembran, A. Tricoli, and D. Nisbet, “Engineering of chitosan-hydroxyapatite-magnetite hierarchical scaffolds for guided bone growth,” Materials, 12 (2019). Article number 2321. https://doi.org/10.3390/ma12142321
  11. H. Sadeghzadeh, H. Dianat-Moghadam, A. R. Del Bakhshayesh, D. Mohammadnejad, and A. Mehdipour, “A review on the effect of nanocomposite scaffolds reinforced with magnetic nanoparticles in osteogenesis and healing of bone injuries,” Stem Cell Res. Ther., 14 (2023). Article number 194. https://doi.org/10.1186/s13287-023-03426-0
  12. A. Mashak, S. Bazraee, and H.Mobedi, “Advances in drug delivery and biomedical applications of hydroxyapatite-based systems: a review,” Bull. Mater. Sci., 45 (2022). Article number 183. https://doi.org/10.1007/s12034-022-02758-6
  13. C. Feng, L. Chao, Z. Ying-Jie, Z. Xin-Yu, L. Bing-Qiang, and W. Jin, “Magnetic nanocomposite of hydroxyapatite ultrathin nanosheets/Fe3O4 nanoparticles: microwave-assisted rapid synthesis and application in pH-responsive drug release,” Biomater. Sci., 1, Is. 10 (2013). Article number 1074. https://doi.org/10.1039/c3bm60086f
  14. J. Li, X. Yi, L. Liu, X. Wang, and J. Ai,”Advances in tumor nanotechnology: theragnostic implications in tumors via targeting regulated cell death,” Apoptosis, 28, 1198-1215 (2023). https://doi.org/10.1007/s10495-023-01851-3
  15. A. O. Synytsia, O. E. Sych, T. E. Babutina, T. V. Tomila, and O. I. Bykov, “Biogenic hydroxyapatite-based composites modified by magnetite and chitosan: synthesis, phase composition and structure,” Func. Mater., 29, Is. 2, 299-304 (2022). https://doi.org/10.15407/fm29.02.299
  16. A. Synytsia, O. Sych, A. Iatsenko, T. Babutina, T. Tomila, O. Bykov, O. Olifan, T. Lobunets, A. Perekos, and N. Boshytska, “Effect of type and parameters of synthesis on the properties of magnetite nanoparticles,” Appl. Nanosci, 12, 929-937 (2022). https://doi.org/10.1007/s13204-021-01797-5
  17. E. E. Sych, “Investigation of chemical, physical and technological properties of porous granules of biogenic hydroxyapatite,” Visnyk Natsionalnogo Tekhnichnogo Universytetu “KhPI” [in Russian], Special Issue: Chemistry, Chemical Technology and Ecology, 22, 166-170 (2009).
  18. A. Synytsia, P. Zaremba, S. Zahorodnia, O. Sych, T. Babutina, and I. Kondratenko, “Biogenic hydroxyapatite-based composites modified by magnetite and chitosan: bioresorption in physiological solution and cytotoxicity,” Func. Mater., 29, Is. 4, 506-513 (2022). https://doi.org/10.15407/fm29.04.506
  19. A. Ressler, A. Žužić, I. Ivanišević, N. Kamboj, and H. Ivanković, “Ionic substituted hydroxyapatite for bone regeneration applications: A review,” Open Ceramics, 6 (2021). Article number 100122. https://doi.org/10.1016/j.oceram.2021.100122
  20. S. Balakrishnan, V. P. Padmanabhan, R. Kulandaivelu, T. S. S. Narayanan Nellaiappan, S. Sagadevan, S. Paiman, F. Mohammad, H. A. Al-Lohedan, P. K. Obulapuram, and W. C. Oh, “Influence of iron doping towards the physicochemical and biological characteristics of hydroxyapatite,” Ceram. Int., 47, 5061-5070 (2021). https://doi.org/10.1016/j.ceramint.2020.10.084
  21. A. Burstein, D. Reilly, and M. Martens, “Aging of bone tissue: mechanical properties,” J. Bone Joint Surg., 58, 82-86 (1976). https://doi.org/10.2106/00004623-197658010-00015
  22. S. A. Goldstein, “The mechanical properties of trabecular bone: dependence on anatomic loca-tion and function,” J. Biomech., 20, 1055-1061(1987). https://doi.org/10.1016/0021-9290(87)90023-6
  23. O. Lindahl, “Mechanical properties of dried defatted spongy bone,” Acta Orthop. Scand., 47, Is. 1, 11-19 (1976). https://doi.org/10.3109/17453677608998966
  24. B. Govindan, B. S. Latha, P. Nagamony, F. Ahmed, M. A. Saifi, A. H. Harrath, S. Alwasel, L. Mansour, and E. H. Alsharaeh, “Designed synthesis of nanostructured magnetic hydroxyapatite based drug nanocarrier for anti-cancer drug delivery toward the treatment of human epidermoid carcinoma,” Nanomaterials, 7, Is. 6, 138 (2017). https://doi.org/10.3390/nano7060138
  25. S. Monda, P. Manivasagan, S. Bharathiraja, M. S. Moorthy, H. H. Kim, H. Seo, K. D. Lee, and J. Oh, “Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application,” Int. J. Nanomedicine, 12, 8389-8410 (2017). https://doi.org/10.2147/IJN.S147355
  26. K. Lin, L. Chen, P. Liu, Z. Zou, M. Zhang, Y. Shen, Y. Qiao, X. Liu, and J. Chang, “Hollow magnetic hydroxyapatite microspheres with hierarchically mesoporous microstructure for pH responsive drug delivery,” CrystEngComm., 15, 2999-3008 (2013). https://doi.org/10.1039/c3ce26683d
  27. M. M. Salmani, M. Hashemian, H. J. Yekta, M. G. Nejad, S. Saber-Samandari, and A. Khandan, “Synergic effects of magnetic nanoparticles on hyperthermia-based therapy and controlled drug delivery for bone substitute application,” J. of Superconduct. and Novel Magnetism, 33, 2809-2820 (2020). https://doi.org/10.1007/s10948-020-05530-1